Applications

Common applications of DLS

Protein purification and buffer formulation

• The unique sensitivity to the presence of larger particles or aggregates in an otherwise homogenous solution, makes DLS particularly suitable for protein crystallography and the pursuit of a pure, monodisperse formulation necessary for good quality crystal formation.

Aggregation

• The exquisite sensitivity of DLS makes small numbers of aggregates highly visible

Molecular Weight

• The size measurement given by DLS can be instantly converted to a close approximation of molecular weight provided by standard curves built into software

Micelle Formation

• The speed of DLS makes it easy to observe the dispersion of micelle formations in a series of dilutions

Thermal denaturing

• Molecular changes caused by a change in temperature are easily and quickly observed by DLS

Colloids and Nanoparticles

• Measure the size and polydispersity of manufactured particles.